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Caspase-10 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, FC, IP |
|---|---|
| Primary Accession | Q92851 |
| Clonality | Monoclonal |
| Other Names | Apoptotic protease Mch4; CASP10; Caspase10; FLICE2; ICE like apoptotic protease 4; FADD-like ICE2; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 58951 Da |
| Dilution | WB 1:500~1:2000 IHC 1:50~1:100 IP 1:50 FC 1:50 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human Caspase-10 |
| Description | Caspase-10 is a DED (death effector domain)-containing caspase and functions as an initiator caspase in Fas/TNF induced apoptosis. Four isoforms of caspase-10 have been identified: caspase-10a (Mch4), caspase-10b (FLICE2), caspase-10c and caspase-10d. They have the same prodomain but different mature large and small subdomains). |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | CASP10 |
|---|---|
| Synonyms | MCH4 |
| Function | Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr- Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. |
| Tissue Location | Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
$ 175.00
Cat# AP90974
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