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Huntingtin Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, FC, ICC |
|---|---|
| Primary Accession | P42858 |
| Reactivity | Rat |
| Clonality | Monoclonal |
| Other Names | HD; HDH; HTT; Huntingtin; IT15; ZHD; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 347603 Da |
| Dilution | WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:100~1:500 FC 1:100 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human Huntingtin |
| Description | May play a role in microtubule-mediated transport or vesicle function. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | HTT |
|---|---|
| Synonyms | HD, IT15 |
| Function | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function. |
| Cellular Location | [Huntingtin]: Cytoplasm. Nucleus. Early endosome. Note=The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington disease neurons. Shuttles between cytoplasm and nucleus in a Ran GTPase- independent manner (PubMed:15654337). Recruits onto early endosomes in a Rab5- and HAP40-dependent fashion (PubMed:16476778) |
| Tissue Location | Expressed in the brain cortex (at protein level). Widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 385.00
$ 195.00
Cat# AP91590
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