KCNH7 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | Q9NS40 |
Other Accession | O54852, Q9ER47 |
Reactivity | Human |
Predicted | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 135000 Da |
Antigen Region | 52-78 aa |
Gene ID | 90134 |
---|---|
Other Names | Potassium voltage-gated channel subfamily H member 7, Ether-a-go-go-related gene potassium channel 3, ERG-3, Eag-related protein 3, Ether-a-go-go-related protein 3, hERG-3, Voltage-gated potassium channel subunit Kv113, KCNH7, ERG3 |
Target/Specificity | This KCNH7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-78 amino acids from the N-terminal region of human KCNH7. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | KCNH7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KCNH7 |
---|---|
Synonyms | ERG3 |
Function | Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly. |
Cellular Location | Membrane; Multi-pass membrane protein. |
Tissue Location | Expressed in prolactin-secreting adenomas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
KCNH7 represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This protein encodes a member of the potassium channel, voltage-gated, subfamily H.
References
Alkelai,A., et.al., Psychopharmacology (Berl.) 206 (3), 491-499 (2009)
Couturier,N., et.al., Eur. J. Hum. Genet. 17 (6), 844-847 (2009)
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