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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > 5HT7 Receptor Antibody
5HT7 Receptor Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P34969 |
| Reactivity | Rat |
| Clonality | Monoclonal |
| Other Names | 5 HT 7; 5 HT X; 5-HT-7; 5-HT-X; 5-HT7; 5HT7; htr7; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 53555 Da |
| Dilution | WB 1:500~1:2000 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human 5HT7 Receptor |
| Description | This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | HTR7 {ECO:0000303|Ref.3, ECO:0000312|HGNC:HGNC:5302} |
|---|---|
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:8226867). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35714614, PubMed:8226867). HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:35714614). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | [Isoform A]: Predominant isoform in spleen, caudate and hippocampus. [Isoform D]: Minor isoform in terms of expression. |
Research Areas
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Application Protocols
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$ 350.00
$ 175.00
Cat# AP92505
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