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C7 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | P10643 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 93518 Da |
| Antigen Region | 375-403 aa |
| Gene ID | 730 |
|---|---|
| Other Names | Complement component C7, C7 |
| Target/Specificity | This C7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 375-403 amino acids from the Central region of human C7. |
| Dilution | WB~~1:1000 FC~~1:10~50 IHC-P~~1:50~100 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | C7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | C7 {ECO:0000303|PubMed:3335508, ECO:0000312|HGNC:HGNC:1346} |
|---|---|
| Function | Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22832194, PubMed:26841837, PubMed:27052168, PubMed:30552328, PubMed:3335508). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:22832194, PubMed:30552328, PubMed:3335508). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:22832194, PubMed:30552328, PubMed:3335508). C7 serves as a membrane anchor (PubMed:30552328). During MAC assembly, associates with C5b and C6 to form the C5b-7 complex, a key lipophilic precursor of the MAC complex, which associates with the outer leaflet and reduces the energy for membrane bending (PubMed:30552328, PubMed:32569291). |
| Cellular Location | Secreted. Target cell membrane Note=Secreted as soluble protein (PubMed:3335508). Inserts into the cell membrane of target cells (PubMed:30552328, PubMed:31061395) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection.
References
Davila,S., et.al., Genes Immun. 11 (3), 232-238 (2010)
Kuijpers,T.W., et.al., Mol. Immunol. 47 (4), 671-677 (2010)
Wheeler,H.E., et.al., PLoS Genet. 5 (10), E1000685 (2009)
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