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Desmocollin 3 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q14574 |
| Reactivity | Rat |
| Clonality | Monoclonal |
| Other Names | CDHF3; Desmocollin3; Desmocollin4; DSC; DSC1; DSC2; DSC3; DSC4; HTCP; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 99969 Da |
| Dilution | WB 1:500~1:2000 ICC/IF 1:50~1:200 FC 1:50 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from Desmocollin 3 |
| Description | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | DSC3 |
|---|---|
| Synonyms | CDHF3, DSC4 |
| Function | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (PubMed:19717567). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (By similarity). Essential for successful completion of embryo compaction and embryo development (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome {ECO:0000250|UniProtKB:P55850} Cytoplasm {ECO:0000250|UniProtKB:P55850}. Note=Expressed in the cytoplasm and at the cell membrane of oocytes {ECO:0000250|UniProtKB:P55850} |
| Tissue Location | Expressed throughout the basal and spinous layer of the epidermis with weak expression in the granular layer (at protein level) (PubMed:19717567, PubMed:7665906). Also expressed in the buccal mucosa, esophagus and cervix (at protein level) (PubMed:7665906) |
Research Areas
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Application Protocols
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$ 195.00
$ 385.00
Cat# AP92666
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