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CJ099 Rabbit Polyclonal Antibody
CJ099 Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, IF |
|---|---|
| Primary Accession | Q6UWK7 |
| Reactivity | Rat, Human |
| Host | Polyclonal, Rabbit,IgG |
| Clonality | Polyclonal |
| Calculated MW | 9173 Da |
| Gene ID | 387695 |
|---|---|
| Other Names | Protein GPR15LG, Antimicrobial peptide with 57 amino acid residues, AP-57, Antimicrobial peptide-57, Colon-derived SUSD2 binding factor, CSBF, Protein GPR15 ligand {ECO:0000312|HGNC:HGNC:31428}, Protein GPR15L, Secreted protein C10orf99, GPR15LG (HGNC:31428), C10orf99, GPR15L |
| Storage Conditions | -20℃ |
| Name | GPR15LG (HGNC:31428) |
|---|---|
| Synonyms | C10orf99, GPR15L |
| Function | Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May regulate keratinocyte proliferation (PubMed:29872130). In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (PubMed:35704588). |
| Cellular Location | Secreted |
| Tissue Location | Expressed at high levels in colon, and cervix and at moderate level in tonsil (PubMed:25585381, PubMed:28900043). Highly reduced expression in primary colon cancer tissues compared with that in adjacent tissues (PubMed:25351403). Highest levels of expression detected in stomach and colon; expressed in epithelium of skin and esophagus, and in some tumor and/or tumor adjacent tissues (TAT), including TAT of esophagus cancer, hepatocellular carcinoma (HCC), squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and invasive ductal carcinoma (IDC) tissues (at protein level) (PubMed:25585381) Highly expressed by inflammatory differentiated keratinocytese (PubMed:35704588). |
Research Areas
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP93323
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