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ANR11 Rabbit Polyclonal Antibody
ANR11 Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, IF |
|---|---|
| Primary Accession | Q6UB99 |
| Reactivity | Rat, Human |
| Host | Polyclonal, Rabbit,IgG |
| Clonality | Polyclonal |
| Calculated MW | 297913 Da |
| Gene ID | 29123 |
|---|---|
| Other Names | Ankyrin repeat domain-containing protein 11, Ankyrin repeat-containing cofactor 1, ANKRD11, ANCO1 |
| Dilution | IHC~~1:100~500 IF~~1:50~200 |
| Storage Conditions | -20℃ |
| Name | ANKRD11 |
|---|---|
| Synonyms | ANCO1 |
| Function | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). |
| Cellular Location | Nucleus {ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25413698, ECO:0000269|PubMed:25556659, ECO:0000269|Ref.1}. Note=Localizes to chromatin during prometaphase |
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Provided below are standard protocols that you may find useful for product applications.
Background
This locus encodes an ankryin repeat domain-containing protein. The encoded protein inhibits ligand-dependent activation of transcription. Mutations in this gene have been associated with KBG syndrome, which is characterized by macrodontia, distinctive craniofacial features, short stature, skeletal anomalies, global developmental delay, seizures and intellectual disability. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2 and X. [provided by RefSeq, Jan 2012],
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