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GPR50 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - GPR50 Antibody (Center) AP9343c
    Western blot analysis of GPR50 Antibody (Center) (Cat. #AP9343c) in K562 cell line lysates (35ug/lane). GPR50 (arrow) was detected using the purified Pab.
    detail
  • FC - GPR50 Antibody (Center) AP9343c
    GPR50 Antibody (Center) (Cat. #AP9343c) flow cytometry analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, WB, E
Primary Accession Q13585
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 67369 Da
Antigen Region 316-344 aa
Additional Information
Gene ID 9248
Other Names Melatonin-related receptor, G protein-coupled receptor 50, H9, GPR50
Target/Specificity This GPR50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 316-344 amino acids from the Central region of human GPR50.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGPR50 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR50
Function G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration (PubMed:19699797). Promotes self- renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways (By similarity). Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalisation (PubMed:21858214). Plays also a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration (PubMed:29572483).
Cellular Location Cell membrane; Multi-pass membrane protein. Postsynaptic density
Tissue Location Hypothalamus and pituitary.
Research Areas
Citations (0)
citation

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Background

Melatonin-related receptor expression has been documented from human CNS tissues, specifically in hypothalamus and pituitary, but not in human peripheral tissues. In animals, expression has also been seen in the CNS, and peripheral tissues.

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$ 182.50
$ 70.00
Cat# AP9343c
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