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Smc3 (13R9) Rat Monoclonal Antibody
Smc3 (13R9) Rat Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q9CW03 |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 141556 Da |
| Gene ID | 13006 |
|---|---|
| Other Names | Structural maintenance of chromosomes protein 3, SMC protein 3, SMC-3, Basement membrane-associated chondroitin proteoglycan, Bamacan, Chondroitin sulfate proteoglycan 6, Chromosome segregation protein SmcD, Mad member-interacting protein 1, Smc3, Bam, Bmh, Cspg6, Mmip1, Smc3l1, Smcd |
| Storage Conditions | -20℃ |
| Name | Smc3 |
|---|---|
| Synonyms | Bam, Bmh, Cspg6, Mmip1, Smc3l1, Smcd |
| Function | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. |
| Cellular Location | Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser-1083 is preferentially associated with unsynapsed chromosomal regions |
| Tissue Location | Spermatocytes (at protein level). Widely expressed, with higher expression in testis and brain |
Research Areas
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP93634
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