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Rab11b (6D13) Rat Monoclonal Antibody
Rab11b (6D13) Rat Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P46638 |
|---|---|
| Clonality | Monoclonal |
| Calculated MW | 24489 Da |
| Gene ID | 19326 |
|---|---|
| Other Names | Ras-related protein Rab-11B, 3.6.5.2, Rab11b |
| Storage Conditions | -20℃ |
| Name | Rab11b {ECO:0000312|MGI:MGI:99425} |
|---|---|
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation. On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (By similarity). |
| Cellular Location | Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O35509}; Lipid-anchor {ECO:0000250|UniProtKB:O35509}; Cytoplasmic side {ECO:0000250|UniProtKB:O35509}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q15907}; Lipid-anchor {ECO:0000250|UniProtKB:Q15907}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15907}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q15907}. Note=Colocalizes with RAB11AFIP1 on punctate vesicles. {ECO:0000250|UniProtKB:Q15907} |
| Tissue Location | Abundantly expressed in brain, heart and testis. Also detected in kidney and pancreatic islets |
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$ 385.00
Cat# AP93647
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