|Application ||FC, IHC-P, WB, E|
|Calculated MW||17663 Da|
|Antigen Region||16-45 aa|
|Other Names||Mitotic spindle-associated MMXD complex subunit MIP18, MSS19-interacting protein of 18 kDa, Protein FAM96B, FAM96B, MIP18|
|Target/Specificity||This FA96B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human FA96B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FA96B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004, PubMed:22678362, PubMed:22678361, PubMed:29848660). As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins (PubMed:23891004, PubMed:29848660). As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633). Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis (PubMed:29848660).|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody Note=In mitosis, localizes to the spindle during metaphase and the spindle midbody during telophase (PubMed:29848660). Co-localizes with KIF4A to the spindle midzone and midbody during telophase and cytokinesis (PubMed:29848660).|
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Provided below are standard protocols that you may find useful for product applications.
Ewing,R.M. Mol. Syst. Biol. 3, 89 (2007)
Wistow,G. Mol. Vis. 8, 171-184 (2002)
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