|Application ||FC, WB, E|
|Other Accession||Q4QQU6, Q8BGT7, Q3T045|
|Calculated MW||26711 Da|
|Antigen Region||11-41 aa|
|Other Names||Survival of motor neuron-related-splicing factor 30, 30 kDa splicing factor SMNrp, SMN-related protein, Survival motor neuron domain-containing protein 1, SMNDC1, SMNR, SPF30|
|Target/Specificity||This SMNDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-41 amino acids from the N-terminal region of human SMNDC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SMNDC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Necessary for spliceosome assembly. Overexpression causes apoptosis.|
|Cellular Location||Nucleus speckle. Nucleus, Cajal body. Note=Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies|
|Tissue Location||Detected at intermediate levels in skeletal muscle, and at low levels in heart and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
This protein is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This protein is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene.
Little,J.T. J. Biol. Chem. 283 (13), 8145-8152 (2008)
Ewing,R.M., Mol. Syst. Biol. 3, 89 (2007)
Beausoleil,S.A., Nat. Biotechnol. 24 (10), 1285-1292 (2006)
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