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Frzb (10J17) Rabbit Monoclonal Antibody

Frzb (10J17) Rabbit Monoclonal Antibody

     
  •  - Frzb (10J17) Rabbit Monoclonal Antibody AP93781
    Western blot analysis of extracts from Rat kidney,Mouse brain tissue using AP93781 at 1:1000.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IF, FC, ICC, IP
Primary Accession P97401
Reactivity Mouse
Clonality Monoclonal
Calculated MW 36011 Da
Additional Information
Gene ID 20378
Other Names Secreted frizzled-related protein 3, sFRP-3, Frezzled, Fritz, Frizzled-related protein 1, FrzB-1, Frzb, Fiz, Fre, Frzb1, Sfrp3
Dilution WB~~1:1000
IF~~1:50~200
FC~~1:10~50
ICC~~N/A
IP~~N/A
Storage Conditions-20℃
Protein Information
Name Frzb
Synonyms Fiz, Fre, Frzb1, Sfrp3
Function Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (By similarity).
Cellular Location Secreted.
Tissue Location Expressed in kidney, brain, testis. Weak expression in spleen and heart.
Citations (0)
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Background

Enables Wnt-protein binding activity. Involved in negative regulation of Wnt signaling pathway. Acts upstream of or within several processes, including animal organ development; negative regulation of cartilage development; and negative regulation of cell differentiation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human FRZB (frizzled related protein). [provided by Alliance of Genome Resources, Apr 2022]

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$ 385.00
Cat# AP93781
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