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Frzb (10J17) Rabbit Monoclonal Antibody
Frzb (10J17) Rabbit Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, FC, ICC, IP |
|---|---|
| Primary Accession | P97401 |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 36011 Da |
| Gene ID | 20378 |
|---|---|
| Other Names | Secreted frizzled-related protein 3, sFRP-3, Frezzled, Fritz, Frizzled-related protein 1, FrzB-1, Frzb, Fiz, Fre, Frzb1, Sfrp3 |
| Dilution | WB~~1:1000 IF~~1:50~200 FC~~1:10~50 ICC~~N/A IP~~N/A |
| Storage Conditions | -20℃ |
| Name | Frzb |
|---|---|
| Synonyms | Fiz, Fre, Frzb1, Sfrp3 |
| Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (By similarity). |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in kidney, brain, testis. Weak expression in spleen and heart. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Enables Wnt-protein binding activity. Involved in negative regulation of Wnt signaling pathway. Acts upstream of or within several processes, including animal organ development; negative regulation of cartilage development; and negative regulation of cell differentiation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human FRZB (frizzled related protein). [provided by Alliance of Genome Resources, Apr 2022]
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