PLVAP Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, WB, E |
---|---|
Primary Accession | Q9BX97 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 50594 Da |
Antigen Region | 214-242 aa |
Gene ID | 83483 |
---|---|
Other Names | Plasmalemma vesicle-associated protein, Fenestrated endothelial-linked structure protein, Plasmalemma vesicle protein 1, PV-1, PLVAP, FELS, PV1 |
Target/Specificity | This PLVAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-242 amino acids from the Central region of human PLVAP. |
Dilution | WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PLVAP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PLVAP |
---|---|
Synonyms | FELS, PV1 |
Function | Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development. |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9WV78}; Single-pass type II membrane protein. Membrane, caveola {ECO:0000250|UniProtKB:Q9WV78}; Single-pass type II membrane protein. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9WV78}. Note=Membrane-associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region. {ECO:0000250|UniProtKB:Q9WV78} |
Tissue Location | Expressed in lung, kidney, heart, aorta, placenta, muscle, pituitary gland, adrenals, mammary gland, bladder, lymph node, bone marrow, trachea, digestive tract, liver and tumor-associated endothelium. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PLVAP involved in the formation of stomatal and fenestral diaphragms of caveolae. This protein may function in microvascular permeability.
References
Keuschnigg, J., et al. Blood 114(2):478-484(2009)
Carson-Walter, E.B., et al. Clin. Cancer Res. 11(21):7643-7650(2005)
Strickland, L.A., et al. J. Pathol. 206(4):466-475(2005)
Stan, R.V., et al. Mol. Biol. Cell 15(8):3615-3630(2004)
Hnasko, R., et al. J. Endocrinol. 175(3):649-661(2002)
Stan, R.V., et al. Genomics 72(3):304-313(2001)
Stan, R.V., et al. J. Cell Biol. 145(6):1189-1198(1999)
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