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GC-C (17B1) Rabbit Monoclonal Antibody
GC-C (17B1) Rabbit Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q3UWA6 |
| Reactivity | Rat, Mouse |
| Clonality | Monoclonal |
| Calculated MW | 123232 Da |
| Gene ID | 14917 |
|---|---|
| Other Names | Guanylyl cyclase C, GC-C, 4.6.1.2, Heat-stable enterotoxin receptor, STA receptor, Intestinal guanylate cyclase, Gucy2c, Guc2c |
| Storage Conditions | -20℃ |
| Name | Gucy2c |
|---|---|
| Synonyms | Guc2c |
| Function | Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P25092}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P25092} Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P25092}; Single- pass type I membrane protein {ECO:0000250|UniProtKB:P25092}. Note=The 145 kDa plasma membrane form of GUCY2C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form {ECO:0000250|UniProtKB:P25092} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin (By similarity).
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