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CD38 (14S19) Rabbit Monoclonal Antibody
CD38 (14S19) Rabbit Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | P56528 |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 34408 Da |
| Gene ID | 12494 |
|---|---|
| Other Names | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, 3.2.2.-, 3.2.2.6, 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, 2.4.99.20, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, ADPRC 1, Cyclic ADP-ribose hydrolase 1, cADPR hydrolase 1, I-19, NIM-R5 antigen, CD38, Cd38 |
| Dilution | WB~~1:1000 IHC~~1:100~500 |
| Storage Conditions | -20℃ |
| Name | Cd38 |
|---|---|
| Function | Synthesizes the second messengers cyclic ADP-ribose (cADPR) and nicotinate-adenine dinucleotide phosphate (NAADP), the former a second messenger for glucose-induced insulin secretion, the latter a Ca(2+) mobilizer (PubMed:11829748). Also has cADPR hydrolase activity (By similarity). |
| Cellular Location | Membrane; Single-pass type II membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Knockout mice deficient for this gene display altered humoral immune responses. In addition, knockout mice exhibit higher locomotor activity and defects in nurturing and social behaviors. [provided by RefSeq, Sep 2015]
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