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CXXC4 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | Q9H2H0 |
| Other Accession | Q9EQC9, Q6NXI8 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 20978 Da |
| Antigen Region | 158-185 aa |
| Other Names | CXXC-type zinc finger protein 4, Inhibition of the Dvl and axin complex protein, CXXC4, IDAX |
|---|---|
| Target/Specificity | This CXXC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 158-185 amino acids from the C-terminal region of human CXXC4. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CXXC4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CXXC4 |
|---|---|
| Synonyms | IDAX |
| Function | Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl- CpG (PubMed:29276034). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9EQC9}. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
CXXC4 acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.
References
Kojima, T., et al. Oncogene 28(2):297-305(2009)
Hino, S., et al. Mol. Cell. Biol. 21(1):330-342(2001)
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