|Application ||FC, IHC-P, WB, E|
|Calculated MW||120308 Da|
|Antigen Region||510-539 aa|
|Other Names||Adenylate cyclase type 7, ATP pyrophosphate-lyase 7, Adenylate cyclase type VII, Adenylyl cyclase 7, ADCY7, KIAA0037|
|Target/Specificity||This ADCY7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 510-539 amino acids from the Central region of human ADCY7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADCY7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:23229509, PubMed:18541530). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (PubMed:23842570, PubMed:23229509). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
ADCY7 encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences.
Townsend, P.D., et al. J. Biol. Chem. 284(2):784-791(2009)
Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
Jiang, L.I., et al. J. Biol. Chem. 283(34):23429-23439(2008)
Kou, J., et al. Alcohol. Clin. Exp. Res. 31(9):1467-1472(2007)
Hines, L.M., et al. J. Neurosci. 26(48):12609-12619(2006)
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