PNPO Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9NVS9 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 29988 Da |
Antigen Region | 232-261 aa |
Gene ID | 55163 |
---|---|
Other Names | Pyridoxine-5'-phosphate oxidase, Pyridoxamine-phosphate oxidase, PNPO |
Target/Specificity | This PNPO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-261 amino acids from the C-terminal region of human PNPO. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PNPO Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PNPO |
---|---|
Function | Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). |
Tissue Location | Ubiquitous. Expressed in liver, brain, lung, prostate and stomach (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine.
References
Musayev, F.N., et al. J. Biol. Chem. 284(45):30949-30956(2009)
Khayat, M., et al. Mol. Genet. Metab. 94(4):431-434(2008)
Song, H., et al. Schizophr. Res. 97 (1-3), 264-270 (2007) :
Mills, P.B., et al. Hum. Mol. Genet. 14(8):1077-1086(2005)
Kang, J.H., et al. Eur. J. Biochem. 271(12):2452-2461(2004)
Musayev, F.N., et al. Protein Sci. 12(7):1455-1463(2003)
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