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PNPO Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NVS9 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 29988 Da |
| Antigen Region | 232-261 aa |
| Gene ID | 55163 |
|---|---|
| Other Names | Pyridoxine-5'-phosphate oxidase, Pyridoxamine-phosphate oxidase, PNPO |
| Target/Specificity | This PNPO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-261 amino acids from the C-terminal region of human PNPO. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PNPO Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PNPO |
|---|---|
| Function | Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). |
| Tissue Location | Ubiquitous. Expressed in liver, brain, lung, prostate and stomach (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine.
References
Musayev, F.N., et al. J. Biol. Chem. 284(45):30949-30956(2009)
Khayat, M., et al. Mol. Genet. Metab. 94(4):431-434(2008)
Song, H., et al. Schizophr. Res. 97 (1-3), 264-270 (2007) :
Mills, P.B., et al. Hum. Mol. Genet. 14(8):1077-1086(2005)
Kang, J.H., et al. Eur. J. Biochem. 271(12):2452-2461(2004)
Musayev, F.N., et al. Protein Sci. 12(7):1455-1463(2003)
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