|Application ||IF, FC, IHC-P, WB, E|
|Calculated MW||18042 Da|
|Antigen Region||33-61 aa|
|Other Names||Low molecular weight phosphotyrosine protein phosphatase, LMW-PTP, LMW-PTPase, Adipocyte acid phosphatase, Low molecular weight cytosolic acid phosphatase, Red cell acid phosphatase 1, ACP1|
|Target/Specificity||This ACP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-61 amino acids from the N-terminal region of human ACP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.|
|Tissue Location||T-lymphocytes express only isoform 2.|
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Provided below are standard protocols that you may find useful for product applications.
ACP1 belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios.
Saccucci, P., et al. Med. Sci. Monit. 15 (10), CR511-CR517 (2009) : Shu, Y.H., et al. J. Clin. Endocrinol. Metab. 94(10):4094-4102(2009) Apelt, N., et al. Metab. Clin. Exp. 58(10):1415-1423(2009) Banci, M., et al. Cardiology 113(4):236-242(2009) Rousseff, R.T., et al. Neuropediatrics 39(6):354-356(2008)
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