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IL-6R alpha Rabbit pAb
IL-6R alpha Rabbit pAb
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- BACKGROUND
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P22272 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 50455 Da |
| Gene ID | 16194 |
|---|---|
| Other Names | Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1, CD126, Soluble interleukin-6 receptor subunit alpha, sIL6R, Il6ra {ECO:0000312|MGI:MGI:105304}, Il6r |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | Il6ra {ECO:0000312|MGI:MGI:105304} |
|---|---|
| Synonyms | Il6r |
| Function | Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. |
| Cellular Location | [Interleukin-6 receptor subunit alpha]: Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed by dendritic cells. |
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Background
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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