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> home > Products > Primary Antibodies > Antibody Collections > Inflammation mediated by chemokine and cytokine signaling > PLCZ1 Antibody (N-term)
PLCZ1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q86YW0 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 70411 Da |
| Antigen Region | 26-54 aa |
| Gene ID | 89869 |
|---|---|
| Other Names | 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase zeta-1, Phosphoinositide phospholipase C-zeta-1, Phospholipase C-zeta-1, PLC-zeta-1, Testis-development protein NYD-SP27, PLCZ1 (HGNC:19218) |
| Target/Specificity | This PLCZ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-54 amino acids from the N-terminal region of human PLCZ1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PLCZ1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLCZ1 (HGNC:19218) |
|---|---|
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q8K4D7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8K4D7} Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity) {ECO:0000250|UniProtKB:Q8K4D7} |
| Tissue Location | Expressed specifically in testis and sperm. Weakly expressed in pancreatic-duct cells. Up-regulated in pancreatic-duct cells from patients with cystic fibrosis. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Yoon, S.Y., et al. J. Clin. Invest. 118(11):3671-3681(2008)
Ito, M., et al. Biol. Reprod. 78(6):1081-1090(2008)
Yu, Y., et al. Hum. Reprod. 23(2):365-373(2008)
Yoshida, N., et al. Development 134(21):3941-3952(2007)
Zhu, J.X., et al. Cell Biol. Int. 31(5):521-525(2007)
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$ 385.00
$ 150.00
Cat# AP9423a
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