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MRas Rabbit pAb
MRas Rabbit pAb
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- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O08989 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 23 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from mouse MRas |
| Epitope Specificity | 201-259/259 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). |
| SIMILARITY | Belongs to the small GTPase superfamily. Ras family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | MRas is a member of the RAS superfamily of GTP-binding proteins which are membrane-anchored, intracellular signal transducers responsible for a variety of normal cellular functions. They are oncogenically activated in a significant fraction of tumors. MRas participates in reorganisation of actin cytoskeleton. It is also involved in focal adhesion and can activate MAPK signalling. |
| Gene ID | 17532 |
|---|---|
| Other Names | Ras-related protein M-Ras, 3.6.5.2, Muscle and microspikes Ras, Ras-related protein R-Ras3, X-Ras, Mras, Xras |
| Target/Specificity | Expression highly restricted to the brain and heart. |
| Dilution | WB=1:500-2000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | Mras |
|---|---|
| Synonyms | Xras |
| Function | Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (By similarity). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (By similarity). The formation of the SMP complex only occurs when MRAS is GTP-bound (By similarity). MRAS has low intrinsic GTPase activity and may require additional factors for activation (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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$ 385.00
Cat# AP94748
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