ACAD8 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9UKU7 |
Other Accession | Q9D7B6 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 45070 Da |
Antigen Region | 118-145 aa |
Gene ID | 27034 |
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Other Names | Isobutyryl-CoA dehydrogenase, mitochondrial, 1399-, Activator-recruited cofactor 42 kDa component, ARC42, Acyl-CoA dehydrogenase family member 8, ACAD-8, ACAD8, ARC42, IBD |
Target/Specificity | This ACAD8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-145 amino acids from the Central region of human ACAD8. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ACAD8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ACAD8 (HGNC:87) |
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Synonyms | ARC42, IBD |
Function | Isobutyryl-CoA dehydrogenase which catalyzes the conversion of 2-methylpropanoyl-CoA to (2E)-2-methylpropenoyl-CoA in the valine catabolic pathway (PubMed:11013134, PubMed:12359132, PubMed:16857760). To a lesser extent, also able to catalyze the oxidation of (2S)-2- methylbutanoyl-CoA (PubMed:11013134, PubMed:12359132). |
Cellular Location | Mitochondrion |
Tissue Location | Detected at comparable levels in heart, lung, brain, skeletal muscle, pancreas and placenta. Weakly expressed in liver and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ACAD8 is a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. This protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine.
References
Wollmer, M.A., et al. Neurogenetics 8(3):179-188(2007)
Ma, J., et al. Atherosclerosis 191(1):63-72(2007)
Battaile, K.P., et al. J. Biol. Chem. 279(16):16526-16534(2004)
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