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GINS1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q14691 |
| Other Accession | Q9CZ15 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22988 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 9837 |
|---|---|
| Other Names | DNA replication complex GINS protein PSF1, GINS complex subunit 1, GINS1, KIAA0186, PSF1 |
| Target/Specificity | This GINS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GINS1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GINS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GINS1 (HGNC:28980) |
|---|---|
| Synonyms | KIAA0186, PSF1 |
| Function | Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). |
| Cellular Location | Nucleus. Chromosome. Note=Associates with chromatin |
Provided below are standard protocols that you may find useful for product applications.
Background
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).
References
Nagahama, Y., et al. Cancer Res. 70(3):1215-1224(2010) Kamada, K., et al. Nat. Struct. Mol. Biol. 14(5):388-396(2007)
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