|Application ||WB, IF, FC, IHC-P, E|
|Calculated MW||63429 Da|
|Antigen Region||527-555 aa|
|Other Names||Fanconi anemia group C protein, Protein FACC, FANCC, FAC, FACC|
|Target/Specificity||This FANCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-555 amino acids from the C-terminal region of human FANCC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FANCC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.|
|Cellular Location||Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic|
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Provided below are standard protocols that you may find useful for product applications.
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This protein is for complementation group C.
Barroso, E., et al. Breast Cancer Res. Treat. 118(3):655-660(2009)
McWilliams, R.R., et al. Cancer Epidemiol. Biomarkers Prev. 18(9):2549-2552(2009)
Michiels, S., et al. Carcinogenesis 30(5):763-768(2009)
Palmieri, R.T., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3567-3572(2008)
Sinha, S., et al. Mol. Cancer 7, 84 (2008) :
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