|Application ||WB, E|
|Calculated MW||49715 Da|
|Antigen Region||329-358 aa|
|Other Names||Phospholipase A1 member A, 311-, Phosphatidylserine-specific phospholipase A1, PS-PLA1, PLA1A, NMD, PSPLA1|
|Target/Specificity||This PLA1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-358 amino acids from the Central region of human PLA1A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLA1A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.|
|Tissue Location||Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Phosphatidylserine-specific phospholipase A1-alpha (PLA1A) acts specifically on phosphatidylserine (PS) and 1-acyl-2-lysophosphatidylserine (lyso-PS) to hydrolyze fatty acids at the sn-1 position of these phospholipids.
?Morikawa, R.K., et al. J. Biol. Chem. 284(39):26620-26630(2009)
?Aoki, J., et al. Biochim. Biophys. Acta 1582 (1-3), 26-32 (2002) :
?Wang, J., et al. J. Hum. Genet. 47(11):611-613(2002)
?Nagai, Y., et al. J. Biol. Chem. 274(16):11053-11059(1999)
?van Groningen, J.J., et al. FEBS Lett. 404(1):82-86(1997)
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