|Application ||WB, E|
|Other Accession||P0DJJ3, Q8VD37|
|Calculated MW||89109 Da|
|Antigen Region||1-30 aa|
|Other Names||SH3-containing GRB2-like protein 3-interacting protein 1, Endophilin-3-interacting protein, SGIP1|
|Target/Specificity||This SGIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SGIP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SGIP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.|
|Cellular Location||Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Specifically expressed in brain.|
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Provided below are standard protocols that you may find useful for product applications.
SGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy homeostasis via its interaction with endophilins (see SH3GL3; MIM 603362) (Trevaskis et al., 2005 [PubMed 15919751] and Uezu et al., 2007 [PubMed 17626015]).
Luke, M.M., et al. Stroke 40(2):363-368(2009)
Shiffman, D., et al. Arterioscler. Thromb. Vasc. Biol. 28(1):173-179(2008)
Uezu, A., et al. J. Biol. Chem. 282(36):26481-26489(2007)
Trevaskis, J., et al. Endocrinology 146(9):3757-3764(2005)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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