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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SACM1L Antibody (C-term)   

SACM1L Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SACM1L Antibody (C-term) AP9560b
    Western blot analysis of SACM1L Antibody (C-term) (Cat. #AP9560b) in Jurkat cell line lysates (35ug/lane). SACM1L (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NTJ5
Other Accession Q9ES21, A6QL88
Reactivity Human
Predicted Bovine, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 66967 Da
Antigen Region 408-436 aa
Additional Information
Gene ID 22908
Other Names Phosphatidylinositide phosphatase SAC1, 313-, Suppressor of actin mutations 1-like protein, SACM1L, KIAA0851
Target/Specificity This SACM1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 408-436 amino acids from the C-terminal region of human SACM1L.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSACM1L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed:24209621, PubMed:27044890, PubMed:29461204, PubMed:30659099). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (PubMed:29461204, PubMed:24209621, PubMed:30659099). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (PubMed:30659099).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane. Note=Trafficking between the ER and Golgi is regulated by nutrient status and by TMEM39A (PubMed:31806350) Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) in the presence of phosphatidylinositol-4,5-bisphosphate (PubMed:27044890).
Tissue Location Detected in heart, brain, lung, liver, kidney, pancreas and testis.
Research Areas
Citations (0)

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Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2 (By similarity).


?Liu, Y., et al. Mol. Biol. Cell 19(7):3080-3096(2008)
?Rohde, H.M., et al. J. Biol. Chem. 278(52):52689-52699(2003)
?Zhong, R., et al. Plant Physiol. 132(2):544-555(2003)
?Kiss, H., et al. Genomics 73(1):10-19(2001)

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Cat# AP9560b
Availability: Back Order
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