|Application ||WB, E|
|Calculated MW||126689 Da|
|Antigen Region||55-83 aa|
|Other Names||Protein-methionine sulfoxide oxidase MICAL2, 11413-, Molecule interacting with CasL protein 2, MICAL-2, MICAL2, KIAA0750, MICAL2PV1, MICAL2PV2|
|Target/Specificity||This MICAL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human MICAL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MICAL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0750, MICAL2PV1, MICAL2PV2|
|Function||Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A- dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334).|
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Provided below are standard protocols that you may find useful for product applications.
Ashida, S., et al. Clin. Cancer Res. 12(9):2767-2773(2006)
Fischer, J., et al. Biochem. Biophys. Res. Commun. 328(2):415-423(2005)
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