LONP2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q86WA8 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 94617 Da |
Antigen Region | 104-132 aa |
Gene ID | 83752 |
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Other Names | Lon protease homolog 2, peroxisomal {ECO:0000255|HAMAP-Rule:MF_03121}, 3421- {ECO:0000255|HAMAP-Rule:MF_03121}, Lon protease-like protein 2 {ECO:0000255|HAMAP-Rule:MF_03121}, Lon protease 2 {ECO:0000255|HAMAP-Rule:MF_03121}, Peroxisomal Lon protease {ECO:0000255|HAMAP-Rule:MF_03121}, LONP2 {ECO:0000255|HAMAP-Rule:MF_03121}, LONP |
Target/Specificity | This LONP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-132 amino acids from the N-terminal region of human LONP2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | LONP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LONP2 {ECO:0000255|HAMAP-Rule:MF_03121} |
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Synonyms | LONP |
Function | ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. |
Cellular Location | Peroxisome matrix {ECO:0000255|HAMAP- Rule:MF_03121, ECO:0000269|PubMed:14561759, ECO:0000269|PubMed:18281296, ECO:0000269|PubMed:22002062} |
Tissue Location | Widely expressed, with high levels in the liver, kidney and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
LONP2 is probable serine protease which may be involved in peroxisome biogenesis (By similarity).
References
Omi, S., et al. J. Biochem. 143(5):649-660(2008)
Kikuchi, M., et al. J. Biol. Chem. 279(1):421-428(2004)
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