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HSPB6 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - HSPB6 Antibody (Center) AP9629C
    Western blot analysis of HSPB6 Antibody (Center) (Cat. #AP9629c) in mouse heart tissue lysates (35ug/lane). HSPB6 (arrow) was detected using the purified Pab.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O14558
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 17136 Da
Antigen Region 91-120 aa
Additional Information
Gene ID 126393
Other Names Heat shock protein beta-6, HspB6, Heat shock 20 kDa-like protein p20, HSPB6
Target/Specificity This HSPB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-120 amino acids from the Central region of human HSPB6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHSPB6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSPB6
Function Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.
Cellular Location Cytoplasm. Nucleus. Secreted Note=Translocates to nuclear foci during heat shock
Research Areas
Citations (0)

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Background

HSPB6 is associated with actin (see MIM 102540) and modulates smooth muscle relaxation (Tessier et al., 2003 [PubMed 12842460]).

References

Fuchs, M., et al. Biochem. J. 425(1):245-255(2010)
Qian, J., et al. Circ. Res. 105(12):1223-1231(2009)
Bagneris, C., et al. J. Mol. Biol. 392(5):1242-1252(2009)

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Cat# AP9629C
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