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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > ADPRHL2 Antibody (N-term)
ADPRHL2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q9NX46 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38947 Da |
| Antigen Region | 87-114 aa |
| Gene ID | 54936 |
|---|---|
| Other Names | Poly(ADP-ribose) glycohydrolase ARH3, ADP-ribosylhydrolase 3, [Protein ADP-ribosylarginine] hydrolase-like protein 2, ADPRHL2, ARH3 |
| Target/Specificity | This ADPRHL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-114 amino acids from the N-terminal region of human ADPRHL2. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ADPRHL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADPRS (HGNC:21304) |
|---|---|
| Function | ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP- ribose and acts on different substrates, such as proteins ADP- ribosylated on serine and threonine, free poly(ADP-ribose) and O- acetyl-ADP-D-ribose (PubMed:21498885, PubMed:29907568, PubMed:30045870, PubMed:30401461, PubMed:30830864, PubMed:33186521, PubMed:33769608, PubMed:33894202, PubMed:34019811, PubMed:34321462, PubMed:34479984, PubMed:34625544). Specifically acts as a serine mono-ADP- ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response (PubMed:28650317, PubMed:29234005, PubMed:30045870, PubMed:33186521, PubMed:34019811, PubMed:34625544). Serine ADP- ribosylation of proteins constitutes the primary form of ADP- ribosylation of proteins in response to DNA damage (PubMed:29480802, PubMed:33186521, PubMed:34625544). Does not hydrolyze ADP-ribosyl- arginine, -cysteine, -diphthamide, or -asparagine bonds (PubMed:16278211, PubMed:33769608). Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (PubMed:16278211). Also hydrolyzes free poly(ADP-ribose) in mitochondria (PubMed:22433848). Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins (PubMed:17075046, PubMed:21498885). Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl- ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers (PubMed:21498885). |
| Cellular Location | Nucleus. Cytoplasm. Chromosome Mitochondrion matrix Note=Recruited to DNA lesion regions following DNA damage; ADP-D- ribose-recognition is required for recruitment to DNA damage sites |
| Tissue Location | Ubiquitous (PubMed:16278211). Expressed in skin fibroblasts (PubMed:30830864). |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
ADPRHL2 is a member of the ADP-ribosylglycohydrolase family. The enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.
References
Niere, M., et al. Mol. Cell. Biol. 28(2):814-824(2008)
Ono, T., et al. Proc. Natl. Acad. Sci. U.S.A. 103(45):16687-16691(2006)
Mueller-Dieckmann, C., et al. Proc. Natl. Acad. Sci. U.S.A. 103(41):15026-15031(2006)
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$ 385.00
$ 150.00
Cat# AP9723a
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