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CD7 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CD7 Antibody (Center) AP9733C
    Western blot analysis of CD7 Antibody (Center) (Cat. #AP9733c) in mouse spleen tissue lysates (35ug/lane). CD7 (arrow) was detected using the purified Pab.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P09564
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 65-91 aa
Additional Information
Other Names T-cell antigen CD7, GP40, T-cell leukemia antigen, T-cell surface antigen Leu-9, TP41, CD7, CD7
Target/Specificity This CD7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-91 amino acids from the Central region of human CD7.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD7
Function Not yet known.
Cellular Location Membrane; Single-pass type I membrane protein. EMBL; X06180; CAA29546.1; -; mRNA EMBL; M37271; AAA51953.1; -; Genomic_DNA EMBL; BT006696; AAP35342.1; -; mRNA EMBL; BC009293; AAH09293.1; -; mRNA EMBL; BC013297; AAH13297.1; -; mRNA EMBL; D00749; BAA00646.1; -; Genomic_DNA CCDS; CCDS11807.1; - PIR; A39016; A39016 RefSeq; NP_006128.1; NM_006137.6 SMR; P09564; - BioGRID; 107362; 8 IntAct; P09564; 8 MINT; P09564; - STRING; 9606.ENSP00000312027; - GlyGen; P09564; 2 sites iPTMnet; P09564; - PhosphoSitePlus; P09564; - SwissPalm; P09564; - BioMuta; CD7; - DMDM; 116031; - jPOST; P09564; - MassIVE; P09564; - PaxDb; P09564; - PeptideAtlas; P09564; - PRIDE; P09564; - ProteomicsDB; 52247; - ABCD; P09564; 9 sequenced antibodies Antibodypedia; 3610; 1836 antibodies DNASU; 924; - Ensembl; ENST00000312648; ENSP00000312027; ENSG00000173762 GeneID; 924; - KEGG; hsa:924; - CTD; 924; - DisGeNET; 924; - EuPathDB; HostDB:ENSG00000173762.7; - GeneCards; CD7; - HGNC; HGNC:1695; CD7 HPA; ENSG00000173762; Group enriched (blood, lymphoid tissue) MIM; 186820; gene neXtProt; NX_P09564; - OpenTargets; ENSG00000173762; - PharmGKB; PA26234; - eggNOG; ENOG502SD5I; Eukaryota GeneTree; ENSGT00390000013965; - HOGENOM; CLU_115462_0_0_1; - InParanoid; P09564; - KO; K06457; - OMA; PQDIIYY; - OrthoDB; 1083212at2759; - PhylomeDB; P09564; - TreeFam; TF338565; - PathwayCommons; P09564; - SignaLink; P09564; - BioGRID-ORCS; 924; 5 hits in 872 CRISPR screens GeneWiki; CD7; - GenomeRNAi; 924; - Pharos; P09564; Tbio PRO; PR:P09564; - Proteomes; UP000005640; Chromosome 17 RNAct; P09564; protein Bgee; ENSG00000173762; Expressed in granulocyte and 134 other tissues ExpressionAtlas; P09564; baseline and differential Genevisible; P09564; HS GO; GO:0016021; C:integral component of membrane; TAS:UniProtKB GO; GO:0016020; C:membrane; TAS:ProtInc GO; GO:0005886; C:plasma membrane; TAS:ProtInc GO; GO:0038023; F:signaling receptor activity; TAS:UniProtKB GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW GO; GO:0006955; P:immune response; TAS:UniProtKB GO; GO:0042110; P:T cell activation; TAS:UniProtKB GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; NAS:UniProtKB Gene3D; 2.60.40.10; -; 1 InterPro; IPR039090; CD7 InterPro; IPR007110; Ig-like_dom InterPro; IPR036179; Ig-like_dom_sf InterPro; IPR013783; Ig-like_fold InterPro; IPR003599; Ig_sub InterPro; IPR013106; Ig_V-set PANTHER; PTHR15343; PTHR15343; 1 Pfam; PF07686; V-set; 1 SMART; SM00409; IG; 1 SMART; SM00406; IGv; 1 SUPFAM; SSF48726; SSF48726; 1 PROSITE; PS50835; IG_LIKE; 1 1: Evidence at protein level; Adaptive immunity; Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain; Lipoprotein; Membrane; Palmitate; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1..25 CHAIN 26..240 /note="T-cell antigen CD7" /id="PRO_0000014633" TOPO_DOM 26..180 /note="Extracellular" /evidence="ECO:0000305|PubMed:2479685" TRANSMEM 181..201 /note="Helical" /evidence="ECO:0000305" TOPO_DOM 202..240 /note="Cytoplasmic" /evidence="ECO:0000305|PubMed:2479685" DOMAIN 26..130 /note="Ig-like" REPEAT 145..153 /note="1" REPEAT 154..162 /note="2" REPEAT 163..171 /note="3" REPEAT 172..180 /note="4" REGION 145..180 /note="4 X 9 AA tandem repeats, potential spacer function" LIPID 198 /note="S-palmitoyl cysteine" /evidence="ECO:0000305|PubMed:3501369" CARBOHYD 45 /note="N-linked (GlcNAc...) asparagine" CARBOHYD 96 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973" DISULFID 35..142 /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" DISULFID 48..114 /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" VARIANT 113 /note="T -> A (in dbSNP:rs34579511)" /id="VAR_049855" SEQUENCE 240 AA; 25409 MW; EBBCE08279552108 CRC64; MAGPPRLLLL PLLLALARGL PGALAAQEVQ QSPHCTTVPV GASVNITCST SGGLRGIYLR QLGPQPQDII YYEDGVVPTT DRRFRGRIDF SGSQDNLTIT MHRLQLSDTG TYTCQAITEV NVYGSGTLVL VTEEQSQGWH RCSDAPPRAS ALPAPPTGSA LPDPQTASAL PDPPAASALP AALAVISFLL GLGLGVACVL ARTQIKKLCS WRDKNSAACV VYEDMSHSRC NTLSSPNQYQ
Research Areas
Citations (0)

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Background

CD7 is a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.

References

SundarRaj, S., et al. Mol. Immunol. 46(16):3411-3419(2009)
Seegmiller, A.C., et al. Cytometry B Clin Cytom 76(3):169-174(2009)
Liu, T.Y., et al. Histopathology 54(2):214-220(2009)

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$ 162.50
$ 54.50
Cat# AP9733C
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