|Application ||FC, WB, E|
|Other Accession||Q8CFG5, Q9Z1L5|
|Calculated MW||123011 Da|
|Antigen Region||1026-1053 aa|
|Other Names||Voltage-dependent calcium channel subunit alpha-2/delta-3, Voltage-gated calcium channel subunit alpha-2/delta-3, Voltage-dependent calcium channel subunit alpha-2-3, Voltage-dependent calcium channel subunit delta-3, CACNA2D3|
|Target/Specificity||This CACNA2D3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1026-1053 amino acids from the C-terminal region of human CACNA2D3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CACNA2D3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q- type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Only detected in brain. Not present in lung, testis, aorta, spleen, jejunum, ventricular muscle and kidney (at protein level). According to PubMed:11687876, it is brain-specific, while according to PubMed:11245980, it is widely expressed|
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Provided below are standard protocols that you may find useful for product applications.
CACNA2D3 is a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits.
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Wanajo, A., et al. Gastroenterology 135(2):580-590(2008)
Uhl, G.R., et al. Arch. Gen. Psychiatry 65(6):683-693(2008)
Abo-Dalo, B., et al. Am. J. Med. Genet. A 143A (22), 2668-2674 (2007)
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