|Application ||WB, E|
|Calculated MW||105810 Da|
|Antigen Region||206-235 aa|
|Other Names||GPI ethanolamine phosphate transferase 1, 2---, MCD4 homolog, Phosphatidylinositol-glycan biosynthesis class N protein, PIG-N, PIGN, MCD4|
|Target/Specificity||This PIGN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-235 amino acids from the N-terminal region of human PIGN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PIGN Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). May act as suppressor of replication stress and chromosome missegregation.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
PIGN is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is expressed in the endoplasmic reticulum and transfers phosphoethanolamine (EtNP) to the first mannose of the GPI anchor.
McDonough, C.W., et al. Hum. Genet. (2009) In press :
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Kinoshita, T., et al. Curr Opin Chem Biol 4(6):632-638(2000)
Hong, Y., et al. J. Biol. Chem. 274(49):35099-35106(1999)
Gaynor, E.C., et al. Mol. Biol. Cell 10(3):627-648(1999)
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