|Application ||WB, E|
|Calculated MW||17241 Da|
|Antigen Region||71-100 aa|
|Other Names||Transmembrane inner ear expressed protein, TMIE|
|Target/Specificity||This TMIE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the Central region of human TMIE.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TMIE Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking. Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in many tissues.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a transmembrane inner ear protein. Studies in mouse suggest that this gene is required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. This gene is one of multiple genes responsible for recessive non-syndromic deafness (DFNB), also known as autosomal recessive nonsyndromic hearing loss (ARNSHL), the most common form of congenitally acquired inherited hearing impairment.
Yang, J.J., et al. Int. J. Pediatr. Otorhinolaryngol. (2010) In press
Sirmaci, A., et al. Clin. Genet. 75(6):562-567(2009)
Santos, R.L., et al. J. Mol. Med. 84(3):226-231(2006)
Cho, K.I., et al. Comp. Med. 53(6):642-648(2003)
Naz, S., et al. Am. J. Hum. Genet. 71(3):632-636(2002)
Mitchem, K.L., et al. Hum. Mol. Genet. 11(16):1887-1898(2002)
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