|Application ||FC, IHC-P, WB, E|
|Calculated MW||55209 Da|
|Antigen Region||462-489 aa|
|Other Names||Protein LMBR1L, Limb region 1 protein homolog-like, Lipocalin-1-interacting membrane receptor, Lipocalin-interacting membrane receptor, LMBR1L, KIAA1174, LIMR|
|Target/Specificity||This LMBR1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 462-489 amino acids from the C-terminal region of human LMBR1L.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LMBR1L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta- catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis (PubMed:11287427, PubMed:12591932, PubMed:23964685).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in testis, pituitary gland, adrenal gland, trachea, placenta, thymus, cerebellum, stomach, mammary gland, spinal cord. A weaker expression is detected in colon, pancreas, and prostate.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Rutsch, F., et al. Nat. Genet. 41(2):234-239(2009)
Fluckinger, M., et al. Biochim. Biophys. Acta 1778(1):342-347(2008)
Zhang, Z., et al. Gene 369, 66-71 (2006) :
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Wojnar, P., et al. J. Biol. Chem. 278(18):16209-16215(2003)
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