|Application ||FC, IHC-P, WB, E|
|Calculated MW||104997 Da|
|Antigen Region||207-236 aa|
|Other Names||Disintegrin and metalloproteinase domain-containing protein 19, ADAM 19, 3424-, Meltrin-beta, Metalloprotease and disintegrin dendritic antigen marker, MADDAM, ADAM19, MLTNB|
|Target/Specificity||This ADAM19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 207-236 amino acids from the Central region of human ADAM19.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADAM19 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein.|
|Tissue Location||Expressed in many normal organ tissues and several cancer cell lines|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction.
Hancock, D.B., et al. Nat. Genet. 42(1):45-52(2010)
Styrkarsdottir, U., et al. Nat. Genet. 41(1):15-17(2009)
Chan, M.W., et al. Neoplasia 10(9):908-919(2008)
Tanabe, C., et al. Biochem. Biophys. Res. Commun. 352(1):111-117(2007)
Melenhorst, W.B., et al. Am. J. Transplant. 6(7):1673-1681(2006)
Kang, T., et al. J. Biol. Chem. 277(28):25583-25591(2002)
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