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CLDN15 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | P56746 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24356 Da |
| Antigen Region | 128-157 aa |
| Gene ID | 24146 |
|---|---|
| Other Names | Claudin-15, CLDN15 |
| Target/Specificity | This CLDN15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the Central region of human CLDN15. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CLDN15 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLDN15 (HGNC:2036) |
|---|---|
| Function | Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:12055082, PubMed:13129853, PubMed:31188544, PubMed:35650657, PubMed:36008380). In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and intestinal morphogenesis (By similarity). |
| Cellular Location | Cell junction, tight junction. Cell membrane; Multi-pass membrane protein |
| Tissue Location | Detected in colon (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Plays a major role in tight junction specific obliteration of the intercellular space, through calcium independent cell adhesion activity
References
Van Itallie, C.M., et al. Am. J. Physiol. Renal Physiol. 285 (6), F1078-F1084 (2003)
Gonzalez-Mariscal, L., et al. Prog. Biophys. Mol. Biol. 81(1):1-44(2003)
Tsukita, S., et al. Curr. Opin. Cell Biol. 14(5):531-536(2002)
Colegio, O.R., et al. Am. J. Physiol., Cell Physiol. 283 (1), C142-C147 (2002)
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