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AGXT2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q9BYV1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 57156 Da |
| Antigen Region | 437-463 aa |
| Gene ID | 64902 |
|---|---|
| Other Names | Alanine--glyoxylate aminotransferase 2, mitochondrial, AGT 2, (R)-3-amino-2-methylpropionate--pyruvate transaminase, Beta-ALAAT II, Beta-alanine-pyruvate aminotransferase, D-AIBAT, AGXT2, AGT2 |
| Target/Specificity | This AGXT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-463 amino acids from the C-terminal region of human AGXT2. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AGXT2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AGXT2 |
|---|---|
| Synonyms | AGT2 |
| Function | Multifunctional aminotransferase with a broad substrate specificity (PubMed:20018850, PubMed:23023372, PubMed:24586340). Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor (By similarity). Catalyzes metabolism of not L- but the D- isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3- oxopropanoate and alanine (PubMed:24586340). Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3- oxopropanoate (By similarity). Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA) (PubMed:20018850, PubMed:23023372). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (PubMed:20018850, PubMed:23023372). |
| Cellular Location | Mitochondrion |
| Tissue Location | Expressed in the convoluted tubule in the kidney and in the liver hepatocytes (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor.
References
Rodionov, R.N., et al. J. Biol. Chem. 285(8):5385-5391(2010)
Baker, P.R., et al. Am. J. Physiol., Cell Physiol. 287 (5), C1359-C1365 (2004)
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