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METTL1 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - METTL1 Antibody (Center) AP9887c
    Western blot analysis of METTL1 Antibody (Center) (Cat. #AP9887c) in Ramos cell line lysates (35ug/lane). METTL1 (arrow) was detected using the purified Pab.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9UBP6
Other Accession Q9Z120, Q2YDF1
Reactivity Human
Predicted Bovine, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 31471 Da
Antigen Region 147-175 aa
Additional Information
Gene ID 4234
Other Names tRNA (guanine-N(7)-)-methyltransferase {ECO:0000255|HAMAP-Rule:MF_03055}, 21133 {ECO:0000255|HAMAP-Rule:MF_03055}, Methyltransferase-like protein 1 {ECO:0000255|HAMAP-Rule:MF_03055}, tRNA (guanine(46)-N(7))-methyltransferase {ECO:0000255|HAMAP-Rule:MF_03055}, tRNA(m7G46)-methyltransferase {ECO:0000255|HAMAP-Rule:MF_03055}, METTL1 {ECO:0000255|HAMAP-Rule:MF_03055}, C12orf1
Target/Specificity This METTL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 amino acids from the Central region of human METTL1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMETTL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name METTL1 {ECO:0000255|HAMAP-Rule:MF_03055, ECO:0000312|HGNC:HGNC:7030}
Function Methyltransferase that mediates the formation of N(7)- methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084). Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs (PubMed:31031084). Internal N(7)-methylguanine methylation of mRNAs regulates translation (PubMed:31031084). Also methylates a specific subset of miRNAs, such as let-7 (PubMed:31031083). N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (PubMed:31031083). Acts as a regulator of embryonic stem cell self-renewal and differentiation (By similarity).
Cellular Location Nucleus
Tissue Location Ubiquitous..
Citations (0)

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Background

This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation.

References

Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Nat. Genet. 41(7):824-828(2009)
Cartlidge, R.A., et al. EMBO J. 24(9):1696-1705(2005)
Alexandrov, A., et al. RNA 8(10):1253-1266(2002)

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$ 162.50
$ 54.50
Cat# AP9887c
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