DCP1B Antibody (center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, WB, E |
---|---|
Primary Accession | Q8IZD4 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 67723 Da |
Antigen Region | 261-290 aa |
Gene ID | 196513 |
---|---|
Other Names | mRNA-decapping enzyme 1B, 3---, DCP1B |
Target/Specificity | This DCP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-290 amino acids of human DCP1B. |
Dilution | WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DCP1B Antibody (center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DCP1B |
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Function | May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). |
Cellular Location | Cytoplasm. Nucleus {ECO:0000250|UniProtKB:Q9NPI6} |
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Provided below are standard protocols that you may find useful for product applications.
Background
DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay.
References
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)
Cougot, N., et al. J. Cell Biol. 165(1):31-40(2004)
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