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MARCO Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | Q9UEW3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52658 Da |
| Antigen Region | 13-40 aa |
| Gene ID | 8685 |
|---|---|
| Other Names | Macrophage receptor MARCO, Macrophage receptor with collagenous structure, Scavenger receptor class A member 2, MARCO, SCARA2 |
| Target/Specificity | This MARCO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-40 amino acids of human MARCO. |
| Dilution | WB~~1:500 IHC-P~~1:50~100 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MARCO Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MARCO |
|---|---|
| Synonyms | SCARA2 |
| Function | Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (PubMed:12847263). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein |
| Tissue Location | Expressed in alveolar macrophages (at protein level). Detected in macrophages from various tissues including thymus, kidney, Kupffer cells of liver, and spleen (PubMed:9468508) |
Provided below are standard protocols that you may find useful for product applications.
Background
MARCO is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.
References
Wright, A.K., et al. J. Leukoc. Biol. 86(3):479-489(2009)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Arredouani, M.S., et al. J. Immunol. 175(9):6058-6064(2005)
Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)
Seta, N., et al. Arthritis Rheum. 44(4):931-939(2001)
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