|Application ||WB, IHC-P, E|
|Other Accession||P54824, P54823, Q5ZKB9|
|Predicted||Chicken, Mouse, Xenopus|
|Calculated MW||54417 Da|
|Antigen Region||348-375 aa|
|Other Names||Probable ATP-dependent RNA helicase DDX6, ATP-dependent RNA helicase p54, DEAD box protein 6, Oncogene RCK, DDX6, HLR2, RCK|
|Target/Specificity||This DDX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 348-375 amino acids from the Central region of human DDX6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DDX6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential for the formation of P-bodies, cytosolic membrane- less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:31422817). In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573).|
|Cellular Location||Cytoplasm, P-body. Cytoplasm Nucleus. Note=Upon cellular stress, relocalizes to stress granules (PubMed:26184334)|
|Tissue Location||Abundantly expressed in most tissues.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing.
Broytman, O., et al. Neurobiol. Aging 30(12):1962-1974(2009)
Han, J.W., et al. Nat. Genet. 41(11):1234-1237(2009)
Minshall, N., et al. Mol. Biol. Cell 20(9):2464-2472(2009)
Tritschler, F., et al. Mol. Cell 33(5):661-668(2009)
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