- CITATIONS: 1
|Application ||WB, E|
|Calculated MW||46090 Da|
|Antigen Region||286-315 aa|
|Other Names||UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, GlcNAc-1-P transferase, G1PT, GPT, N-acetylglucosamine-1-phosphate transferase, DPAGT1, DPAGT2|
|Target/Specificity||This DPAGT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-315 amino acids from the Central region of human DPAGT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DPAGT1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
Provided below are standard protocols that you may find useful for product applications.
DPAGT1 encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme.
Nita-Lazar, M., et al. Cancer Res. 69(14):5673-5680(2009)
Bretthauer, R.K. Curr Drug Targets 10(6):477-482(2009)
Wu, X., et al. Hum. Mutat. 22(2):144-150(2003)
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