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URG4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8TCY9 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 104987 Da |
| Antigen Region | 466-495 aa |
| Gene ID | 55665 |
|---|---|
| Other Names | Up-regulator of cell proliferation, HBV X protein up-regulated gene 4 protein, HBxAg up-regulated gene 4 protein, URGCP, KIAA1507 {ECO:0000312|EMBL:BAA960311}, URG4 |
| Target/Specificity | This URG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 466-495 amino acids from the Central region of human URG4. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | URG4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | URGCP |
|---|---|
| Synonyms | KIAA1507 {ECO:0000312|EMBL:BAA96031.1}, |
| Function | May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer. |
| Cellular Location | Cytoplasm. Nucleus. Note=In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei |
| Tissue Location | Strongly expressed in hepatitis B virus-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival.
References
Huang, J., et al. Pathology 41(2):149-154(2009)
Song, J., et al. Neoplasia 8(12):995-1002(2006)
Tsang, H.T., et al. Genomics 88(3):333-346(2006)
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