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> home > Products > Primary Antibodies > Antibody Collections > Recombinant Antibodies > Anti-GUCY2C Reference Antibody (indusatumab)
Anti-GUCY2C Reference Antibody (indusatumab)
Recombinant Antibody
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- BACKGROUND
Application 
| FC, Kinetics, Animal Model |
|---|---|
| Primary Accession | P25092 |
| Reactivity | Rat, Pig, Human |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 145.18 KDa |
| Target/Specificity | GUCY2C |
|---|---|
| Endotoxin | < 0.001EU/ µg,determined by LAL method. |
| Conjugation | Unconjugated |
| Expression system | CHO Cell |
| Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
| Name | GUCY2C {ECO:0000303|PubMed:22521417, ECO:0000312|HGNC:HGNC:4688} |
|---|---|
| Function | Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP (PubMed:11950846, PubMed:1718270, PubMed:22436048, PubMed:22521417, PubMed:23269669). Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C (PubMed:1680854, PubMed:1718270). Also activated by the endogenous peptides guanylin and uroguanylin (PubMed:8381596). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein Endoplasmic reticulum membrane; Single- pass type I membrane protein. Note=The 145 kDa plasma membrane form of GUCY2C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 385.00
Cat# APR10120
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