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> home > Products > Primary Antibodies > Antibody Collections > Recombinant Antibodies > Anti-CLDN18.2 Reference Antibody (zolbetuximab)
Anti-CLDN18.2 Reference Antibody (zolbetuximab)
Recombinant Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, Kinetics, Animal Model |
|---|---|
| Primary Accession | P56856 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 150 KDa |
| Target/Specificity | CLDN18.2 |
|---|---|
| Endotoxin | < 0.001EU/ µg,determined by LAL method. |
| Conjugation | Unconjugated |
| Expression system | CHO Cell |
| Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
| Name | CLDN18 |
|---|---|
| Function | Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (By similarity). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (By similarity). Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (By similarity). Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (By similarity). Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (By similarity). |
| Cellular Location | Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}. Cell membrane {ECO:0000250|UniProtKB:P56857}; Multi-pass membrane protein. Note=Localizes to tight junctions in epithelial cells {ECO:0000250|UniProtKB:P56857} [Isoform A2]: Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}. Lateral cell membrane {ECO:0000250|UniProtKB:P56857} |
| Tissue Location | [Isoform A1]: Expression is restricted to the lung. |
Research Areas
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Application Protocols
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$ 385.00
Cat# APR10189
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